Method for synthesizing dimethyl cysteamine hydrochloride
The invention relates to a method for synthesizing dimethyl cysteamine hydrochloride. The method comprises the following steps: carrying out ring opening and ring closing reaction on 5, 5-dimethyl-2-isopropyl thiazolidine under the action of hydrochloric acid, a solvent, phenylhydrazine and aldehyde...
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| creator | XIAO YUANCHUN |
| description | The invention relates to a method for synthesizing dimethyl cysteamine hydrochloride. The method comprises the following steps: carrying out ring opening and ring closing reaction on 5, 5-dimethyl-2-isopropyl thiazolidine under the action of hydrochloric acid, a solvent, phenylhydrazine and aldehyde to obtain 5, 5-dimethyl-2-substituted thiazolidine mother liquor; directly adding hydrochloric acidinto 5, 5-dimethyl-2-substituted thiazolidine mother liquor and carrying out ring opening reaction to obtain the dimethyl cysteamine hydrochloride. The invention discloses a one-pot preparation process, reaction steps are reduced and the purity is not reduced by controlling the material ratio and charging operation details.
本发明涉及一种合成二甲基半胱胺盐酸盐的方法，包括5,5-二甲基-2-异丙基噻唑烷在盐酸、溶剂、苯肼以及醛的作用下，经开环再关环反应得到5,5-二甲基-2-取代噻唑烷母液；直接向5,5-二甲基-2-取代噻唑烷母液中加入盐酸，经开环反应得到二甲基半胱胺盐酸盐。本发明公开了一锅法的制备工艺，减少了反应步骤，通过控制物料配比及加料操作细节，纯度并未降低。 |
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本发明涉及一种合成二甲基半胱胺盐酸盐的方法，包括5,5-二甲基-2-异丙基噻唑烷在盐酸、溶剂、苯肼以及醛的作用下，经开环再关环反应得到5,5-二甲基-2-取代噻唑烷母液；直接向5,5-二甲基-2-取代噻唑烷母液中加入盐酸，经开环反应得到二甲基半胱胺盐酸盐。本发明公开了一锅法的制备工艺，减少了反应步骤，通过控制物料配比及加料操作细节，纯度并未降低。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200410&DB=EPODOC&CC=CN&NR=110981828A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200410&DB=EPODOC&CC=CN&NR=110981828A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIAO YUANCHUN</creatorcontrib><title>Method for synthesizing dimethyl cysteamine hydrochloride</title><description>The invention relates to a method for synthesizing dimethyl cysteamine hydrochloride. The method comprises the following steps: carrying out ring opening and ring closing reaction on 5, 5-dimethyl-2-isopropyl thiazolidine under the action of hydrochloric acid, a solvent, phenylhydrazine and aldehyde to obtain 5, 5-dimethyl-2-substituted thiazolidine mother liquor; directly adding hydrochloric acidinto 5, 5-dimethyl-2-substituted thiazolidine mother liquor and carrying out ring opening reaction to obtain the dimethyl cysteamine hydrochloride. The invention discloses a one-pot preparation process, reaction steps are reduced and the purity is not reduced by controlling the material ratio and charging operation details.
本发明涉及一种合成二甲基半胱胺盐酸盐的方法，包括5,5-二甲基-2-异丙基噻唑烷在盐酸、溶剂、苯肼以及醛的作用下，经开环再关环反应得到5,5-二甲基-2-取代噻唑烷母液；直接向5,5-二甲基-2-取代噻唑烷母液中加入盐酸，经开环反应得到二甲基半胱胺盐酸盐。本发明公开了一锅法的制备工艺，减少了反应步骤，通过控制物料配比及加料操作细节，纯度并未降低。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD0TS3JyE9RSMsvUiiuzCvJSC3OrMrMS1dIycwFylTmKCRXFpekJuZm5qUqZFSmFOUnZ-TkF2WmpPIwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUknhnP0NDA0sLQwsjC0djYtQAAKgAL6U</recordid><startdate>20200410</startdate><enddate>20200410</enddate><creator>XIAO YUANCHUN</creator><scope>EVB</scope></search><sort><creationdate>20200410</creationdate><title>Method for synthesizing dimethyl cysteamine hydrochloride</title><author>XIAO YUANCHUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110981828A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>XIAO YUANCHUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XIAO YUANCHUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for synthesizing dimethyl cysteamine hydrochloride</title><date>2020-04-10</date><risdate>2020</risdate><abstract>The invention relates to a method for synthesizing dimethyl cysteamine hydrochloride. The method comprises the following steps: carrying out ring opening and ring closing reaction on 5, 5-dimethyl-2-isopropyl thiazolidine under the action of hydrochloric acid, a solvent, phenylhydrazine and aldehyde to obtain 5, 5-dimethyl-2-substituted thiazolidine mother liquor; directly adding hydrochloric acidinto 5, 5-dimethyl-2-substituted thiazolidine mother liquor and carrying out ring opening reaction to obtain the dimethyl cysteamine hydrochloride. The invention discloses a one-pot preparation process, reaction steps are reduced and the purity is not reduced by controlling the material ratio and charging operation details.
本发明涉及一种合成二甲基半胱胺盐酸盐的方法，包括5,5-二甲基-2-异丙基噻唑烷在盐酸、溶剂、苯肼以及醛的作用下，经开环再关环反应得到5,5-二甲基-2-取代噻唑烷母液；直接向5,5-二甲基-2-取代噻唑烷母液中加入盐酸，经开环反应得到二甲基半胱胺盐酸盐。本发明公开了一锅法的制备工艺，减少了反应步骤，通过控制物料配比及加料操作细节，纯度并未降低。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Method for synthesizing dimethyl cysteamine hydrochloride |
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