Method for synthesizing dimethyl cysteamine hydrochloride

The invention relates to a method for synthesizing dimethyl cysteamine hydrochloride. The method comprises the following steps: carrying out ring opening and ring closing reaction on 5, 5-dimethyl-2-isopropyl thiazolidine under the action of hydrochloric acid, a solvent, phenylhydrazine and aldehyde to obtain 5, 5-dimethyl-2-substituted thiazolidine mother liquor; directly adding hydrochloric acidinto 5, 5-dimethyl-2-substituted thiazolidine mother liquor and carrying out ring opening reaction to obtain the dimethyl cysteamine hydrochloride. The invention discloses a one-pot preparation process, reaction steps are reduced and the purity is not reduced by controlling the material ratio and charging operation details. 本发明涉及一种合成二甲基半胱胺盐酸盐的方法，包括5,5-二甲基-2-异丙基噻唑烷在盐酸、溶剂、苯肼以及醛的作用下，经开环再关环反应得到5,5-二甲基-2-取代噻唑烷母液；直接向5,5-二甲基-2-取代噻唑烷母液中加入盐酸，经开环反应得到二甲基半胱胺盐酸盐。本发明公开了一锅法的制备工艺，减少了反应步骤，通过控制物料配比及加料操作细节，纯度并未降低。