Derivative of imidazol-4yl-piperidine, preparation of same and application of same in treatment

Compounds corresponding to the formula (I) in which R1 represents either a hydrogen atom or a straight or branched (C1-C6)alkyl group and A represents either a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group or a 4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 4-methyl-4,5-dihydroimida...

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Hauptverfasser: GERARD DEFOSSE, THOMAS ANDREW PURCELL, SAMIR JEGHAM
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds corresponding to the formula (I) in which R1 represents either a hydrogen atom or a straight or branched (C1-C6)alkyl group and A represents either a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group or a 4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 4-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 4-phenylmethyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 5-methyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl group or a 5,6-dihydro-4H-imidazo[1,5,4-de]quinazolin-2-yl group or a 6-oxo-5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl group or a 5-methyl-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2-yl group which is optionally substituted in the 6-position by a phenylmethyl group, and their addition salts with pharmaceutically acceptable acids. The compounds of the invention are ligands for serotoninergic receptors of 5-HT3 and 5-HT4 types.