Application of Miao medicine pholidota yunnanensis in preparation of medicines for preventing and treating chronic obstructive pulmonary disease

The invention discloses application of Miao medicine pholidota yunnanensis in preparation of medicines for preventing and treating chronic obstructive pulmonary disease (COPD). According to the invention, a COPD inflammatory mechanism is used as a main line. A COPD animal model is established by adopting a method combining cigarette smoking and twice tracheal injection of lipopolysaccharides (LPS). The invention discusses a molecular mechanism of the Miao medicine pholidota yunnanensis for preventing and treating COPD by regulating and controlling a TLR4/NF-kB signal path, provides an experimental basis and a scientific basis for the Miao medicine pholidota yunnanensis for preventing and treating COPD, and also provides a new treatment target for developing a new medicine with an exact curative effect on preventing COPD and an exact material basis. 本发明公开了一种苗药果上叶在制备防治慢性阻塞性肺疾病的药物中的应用。本发明以COPD炎症机制为主线，采用香烟烟熏+两次气管注入脂多糖(LPS)的方法建立COPD动物模型，探讨了苗药果上叶通过调控TLR4/NF-kB信号通路防治COPD的分子机制，为苗药果上叶防治COPD提供实验基础及科学依据，同时也为开发预防COPD疗效确切