HPLC detection method of vildagliptin intermediate-5

The invention relates to the technical field of drug detection, and particularly discloses an HPLC detection method of a vildagliptin intermediate-5. The chromatographic conditions of the HPLC are asfollows: a chromatographic column: octadecylsilane chemically bonded silica is used as a filler; a mobile phase, wherein the mobile phase A is phosphate buffer-acetonitrile-methanol in a volume ratioof 200: (3-5): (3-5); the mobile phase B is phosphate buffer solution-acetonitrile-methanol in a volume ratio of 80: (90-100): (25-35); the column temperature is 33 to 37 DEG C; the detection wavelength is 208 to 212nm; the flow rate is 1.6 to 1.8 ml/min; and the elution mode is gradient elution. The chromatographic peaks in the obtained chromatogram can be completely separated, the separation degree is good, the accuracy of purity detection of the vildagliptin intermediate-5 in the sample can be guaranteed, and reliable guarantee is provided for the quality and curative effect of subsequentlysynthesized vildagliptin.