Method for conditioning antigen-presenting cells

The invention discloses a method for conditioning antigen-presenting cells. Under an in-vitro condition, and in the presence of nucleotide, an antigen is added into the antigen-presenting cells, and the antigen-presenting cells with the added antigen are dendritic cells. Through properties of the an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: JIA ZHENGHU, ZHANG BOQING, NOGUCHI KATSUO
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a method for conditioning antigen-presenting cells. Under an in-vitro condition, and in the presence of nucleotide, an antigen is added into the antigen-presenting cells, and the antigen-presenting cells with the added antigen are dendritic cells. Through properties of the antigen-presenting cells, a medicine for treating cancers and infections can be prepared; in addition,since the nucleotide has a property of activating the antigen-presenting cells, the nucleotide can be used as an antigen-presenting cell activator; by using the antigen-presenting cell activator, theantigen-presenting cells can be conditioned in vitro; and if the antigen-presenting cell activator is applied to a patient, the illness state of the patient can be improved by activating the antigen-presenting cells. 本发明公开了一种抗原呈递细胞的调制方法,为在体外条件、核苷酸存在的情况下,在抗原呈递细胞中加入抗原;所述加入抗原的抗原呈递细胞为树状细胞。本发明利用抗原呈递细胞的性质,可以制造用于治疗癌症和感染症的药物;此外,由于核苷酸具有活化抗原呈递细胞的性质,可以作为抗原呈递细胞活化剂;通过利用抗原呈递细胞活化剂,在体外可以调制抗原呈递细胞;如果将其施用于患者,可以通过活化抗原呈递细胞来改善患者病情。