Applications of rapamycin thiazole derivatives in preparation of anti-Alzheimer's disease drugs

The invention discloses applications of rapamycin thiazole derivatives in preparation of anti-Alzheimer's disease drugs, and specifically relates to applications of a series of the rapamycin thiazolederivatives shown as a structural formula (II) in functions on eliminating beta amyloid protein and in preparation of the anti-Alzheimer's disease drugs. The rapamycin thiazole derivatives have the functions of eliminating the beta amyloid protein by promoting cell autophagy; the compound can improve the memory, space exploration and other cognitive abilities of dementia mice, and has the advantages of being low in cytotoxicity and immunosuppressive activity; and the compound has broad market application prospects on preparing the anti-Alzheimer's disease drugs. 本发明公开了雷帕霉素噻唑类衍生物在制备抗阿尔茨海默症药物中的应用，具体涉及一系列具有结构式(II)所示的雷帕霉素噻唑类衍生物在清除β淀粉样蛋白的作用和制备抗阿尔茨海默症药物中的应用。雷帕霉素噻唑类衍生物具有通过促进细胞自噬清除β淀粉样蛋白的作用，该类化合物可改善痴呆小鼠的记忆、空间探索等认知能力，而且还具有低细胞毒性和低免疫抑制活性等方面的优点，该类化合物对应用于制备抗阿尔茨海默症药物具有广阔的市场应用前景。