MALDI MASS SPECTROMETRY METHOD

A MALDI mass spectrometry method comprises the provision of a test composition comprising an analyte, a matrix material, a solvent for the matrix material and an antisolvent, which facilitates crystallization of the matrix material on the analyte subsequent to droplet generation. Due to the crystallization, a non-spherical particle morphology of the test sample is obtained. The test sample with anon-spherical particle morphology can be distinguished from test samples with an at least substantially spherical particle morphology by sensing a morphology parameter. Based on the sensing result, test samples with a non-spherical particle morphology are selected for ionization and mass spectrometry. The antisolvent is for instance water, and the solvent is an organic solvent. The formed crystalsare in one embodiment crystallized in a hydrate form. As a result, a signature-rich spectrum is obtained MALDI质谱方法包括提供测试组合物，所述测试组合物包含分析物、基质材料、用于基质材料的溶剂和反溶剂，所述组合物有助于在液滴产生之后基质材料在分析物上的结晶。由于结晶，获得了试样的非球形颗粒形态。通过感测形态参数，可以将具有非球形颗粒形态的