NOVEL PROTEIN PORES
The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like poreand a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional c...
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| creator | REMAUT HAN JORDAN MICHAEL ROBERT VAN DER VERREN SANDER EGBERT JAYASINGHE LAKMAL NISHANTHA KILGOUR JOHN JOSEPH SINGH PRATIK RAJ HAMBLEY RICHARD GEORGE VAN GERVEN NANI WALLACE ELIZABETH JAYNE |
| description | The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like poreand a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
本发明涉及新颖蛋白孔及其在分析物检测和表征中的用途。本发明尤其涉及一种由CsgG样孔和经修饰的CsgF肽，或其同源物或突变体形成的分离的孔复合物，从而在纳米孔中并入附加通道收缩段或读取头。本发明还涉及一种跨膜孔复合物和用于产生所述孔复合物的方法，及其在分子感测和核酸测序应用中的用途。 |
| format | Patent |
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本发明涉及新颖蛋白孔及其在分析物检测和表征中的用途。本发明尤其涉及一种由CsgG样孔和经修饰的CsgF肽，或其同源物或突变体形成的分离的孔复合物，从而在纳米孔中并入附加通道收缩段或读取头。本发明还涉及一种跨膜孔复合物和用于产生所述孔复合物的方法，及其在分子感测和核酸测序应用中的用途。</description><language>chi ; eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200324&DB=EPODOC&CC=CN&NR=110914290A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200324&DB=EPODOC&CC=CN&NR=110914290A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>REMAUT HAN</creatorcontrib><creatorcontrib>JORDAN MICHAEL ROBERT</creatorcontrib><creatorcontrib>VAN DER VERREN SANDER EGBERT</creatorcontrib><creatorcontrib>JAYASINGHE LAKMAL NISHANTHA</creatorcontrib><creatorcontrib>KILGOUR JOHN JOSEPH</creatorcontrib><creatorcontrib>SINGH PRATIK RAJ</creatorcontrib><creatorcontrib>HAMBLEY RICHARD GEORGE</creatorcontrib><creatorcontrib>VAN GERVEN NANI</creatorcontrib><creatorcontrib>WALLACE ELIZABETH JAYNE</creatorcontrib><title>NOVEL PROTEIN PORES</title><description>The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like poreand a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
本发明涉及新颖蛋白孔及其在分析物检测和表征中的用途。本发明尤其涉及一种由CsgG样孔和经修饰的CsgF肽，或其同源物或突变体形成的分离的孔复合物，从而在纳米孔中并入附加通道收缩段或读取头。本发明还涉及一种跨膜孔复合物和用于产生所述孔复合物的方法，及其在分子感测和核酸测序应用中的用途。</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD28w9z9VEICPIPcfX0UwjwD3IN5mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hoYGloYmRpYGjsbEqAEAYq0eXg</recordid><startdate>20200324</startdate><enddate>20200324</enddate><creator>REMAUT HAN</creator><creator>JORDAN MICHAEL ROBERT</creator><creator>VAN DER VERREN SANDER EGBERT</creator><creator>JAYASINGHE LAKMAL NISHANTHA</creator><creator>KILGOUR JOHN JOSEPH</creator><creator>SINGH PRATIK RAJ</creator><creator>HAMBLEY RICHARD GEORGE</creator><creator>VAN GERVEN NANI</creator><creator>WALLACE ELIZABETH JAYNE</creator><scope>EVB</scope></search><sort><creationdate>20200324</creationdate><title>NOVEL PROTEIN PORES</title><author>REMAUT HAN ; JORDAN MICHAEL ROBERT ; VAN DER VERREN SANDER EGBERT ; JAYASINGHE LAKMAL NISHANTHA ; KILGOUR JOHN JOSEPH ; SINGH PRATIK RAJ ; HAMBLEY RICHARD GEORGE ; VAN GERVEN NANI ; WALLACE ELIZABETH JAYNE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110914290A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>REMAUT HAN</creatorcontrib><creatorcontrib>JORDAN MICHAEL ROBERT</creatorcontrib><creatorcontrib>VAN DER VERREN SANDER EGBERT</creatorcontrib><creatorcontrib>JAYASINGHE LAKMAL NISHANTHA</creatorcontrib><creatorcontrib>KILGOUR JOHN JOSEPH</creatorcontrib><creatorcontrib>SINGH PRATIK RAJ</creatorcontrib><creatorcontrib>HAMBLEY RICHARD GEORGE</creatorcontrib><creatorcontrib>VAN GERVEN NANI</creatorcontrib><creatorcontrib>WALLACE ELIZABETH JAYNE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>REMAUT HAN</au><au>JORDAN MICHAEL ROBERT</au><au>VAN DER VERREN SANDER EGBERT</au><au>JAYASINGHE LAKMAL NISHANTHA</au><au>KILGOUR JOHN JOSEPH</au><au>SINGH PRATIK RAJ</au><au>HAMBLEY RICHARD GEORGE</au><au>VAN GERVEN NANI</au><au>WALLACE ELIZABETH JAYNE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL PROTEIN PORES</title><date>2020-03-24</date><risdate>2020</risdate><abstract>The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like poreand a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
本发明涉及新颖蛋白孔及其在分析物检测和表征中的用途。本发明尤其涉及一种由CsgG样孔和经修饰的CsgF肽，或其同源物或突变体形成的分离的孔复合物，从而在纳米孔中并入附加通道收缩段或读取头。本发明还涉及一种跨膜孔复合物和用于产生所述孔复合物的方法，及其在分子感测和核酸测序应用中的用途。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | NOVEL PROTEIN PORES |
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