Antibody, and conjugate and preparation method and purpose thereof

The application of the invention relates to a new Trop-2 targeted humanized antibody, and an antibody-medicine conjugate, salt or stereoisomer, a salt solvate or stereoisomer solvate prepared from thenew Trop-2 targeted humanized antibody. Besides, the invention further relates to a medical composition and a medical preparation prepared from the antibody-medicine conjugate, the salt or the stereoisomer, the salt solvate or the stereoisomer solvate. In addition, the invention relates to the antibody-medicine conjugate or the pharmaceutically-acceptable salt or stereoisomer or solvate thereof.The medical composition or the medical preparation disclosed by the application can be used for preparing a composition for restraining cancer cell growth, proliferation or migration and preventing ortreating cancer. 本申请涉及新的靶向Trop-2的人源化抗体，以及由其制备的抗体-药物偶联物，盐或立体异构体，盐或立体异构体的溶剂合物。同时，本申请还涉及由抗体-药物偶联物，盐或立体异构体，盐或立体异构体的溶剂合物制备的药物组合物，药物制剂。此外，本申请的抗体-药物偶联物或者其药学上可接受的盐或立体异构体或者溶剂合物，本申请的药物组合物或药物制剂可用于制备用于抑制癌细胞生长、增殖或迁移，预防或治疗癌症的组合物。