Vocaparane diterpene derivative as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and relates to a vocaparane diterpene derivative as well as a preparation method and application thereof. The structure of the derivative isshown in the specification, wherein A/B rings are in trans-combination, a C ring is a benzene ring, R1, R2, R3, R7 and R8 are any one or more of H, OH, OAc and =O and one or more of esters derived from -OH at the corresponding positions, R6 is H or OH, and R4, R5 and R9 are any one or more of -CH3, -CH2OH, -COOH and -CHO and one or more of esters derived from -CH2OH and -COOH at the correspondingpositions. The vocaparane diterpene and the pharmaceutically acceptable salt, isomer or pharmaceutical composition thereof have immunomodulatory and anti-inflammatory effects, and can be used for preparing immunomodulators or anti-inflammatory drugs, especially anti-ulcerative colitis drugs. 本发明属于医药技术领域，涉及沃卡帕烷(voucapane)型二萜衍生物及其制备方法和应用。所述的衍生物的结构如下：其中，A/B环反式骈合；C环为苯环；R，R，R，R和R为H、OH、OAc、＝O中的任何1个或多个，以及由相应位置的-OH衍生的酯类的一个或多个；R为H或