Foot-and-mouth disease O-type synthetic peptide vaccine and preparation method and application thereof

The invention provides a foot-and-mouth disease O-type synthetic peptide vaccine and a preparation method and application thereof. The foot-and-mouth disease O-type synthetic peptide vaccine comprisesan antigen polypeptide composition, and the antigen polypeptide composition comprises polypeptides shown as a sequence 1 and a sequence 2. The foot-and-mouth disease synthetic peptide vaccine provided by the invention has good immune efficacy, and the antigen of the vaccine is a chemically synthesized polypeptide, does not contain foot-and-mouth disease virus nucleic acid particles, and has highsafety. Therefore, the vaccine provided by the invention can effectively cope with the current foot-and-mouth disease epidemic strain, has no biological safety, is easy for large-scale synthesis, andhas a good application prospect. The invention further provides the preparation method and pharmaceutical application of the polypeptide and the peptide vaccine. 本发明提供一种用于制备口蹄疫O型合成肽疫苗及其制备方法和应用。口蹄疫O型合成肽疫苗包括抗原多肽组合物，抗原多肽组合物包括序列1和序