Triazole alcohol derivatives, and preparation method and application thereof

The invention relates to triazole alcohol derivatives, and a preparation method and application thereof. The chemical structures of the derivatives are shown as a formula I shown in the specification,wherein R represents a structure shown in the specification or a structure shown in the specificatio...

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Hauptverfasser: ZHANG DAZHI, NI-TING JUNHONG, DING ZICHAO, WANG RUINA, JIANG YUANYING, XIE FEI, HAO YUMENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to triazole alcohol derivatives, and a preparation method and application thereof. The chemical structures of the derivatives are shown as a formula I shown in the specification,wherein R represents a structure shown in the specification or a structure shown in the specification; R1 and R2 may individually represent a hydrogen atom, alkyl, aryl, aralkyl, or cycloalkyl; substituents may be located at various positions of the benzene ring in a mono- or poly-substituted manner; the substituents and R3 are selected from: a) a halogen which is F or Cl, b) an electron withdrawing group which is cyano or trifluoromethyl, c) C1-C4 lower alkyl or halogen-substituted C1-C4 lower alkyl, and d) C1-C4 lower alkoxy or halogen-substituted C1-C4 lower alkoxy. The compounds of the invention have strong antifungal activity, have the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs. 本发明涉及一种三氮唑醇类衍生物、其制备方法及应用。所述三氮唑醇类衍生物的化学结构如式I所示,其中R代表或R和R可单