Candesartan cilexetil preparation and preparation method thereof

The invention belongs to the technical field of medical preparation and provides a candesartan cilexetil preparation. The candesartan cilexetil preparation comprises the following components (by weight): 3-5% of candesartan cilexetil, 1-15% of beta-cyclodextrin or its derivative, 20-50% of lactose, 25-45% of pregelatinized starch, 15-25% of microcrystalline cellulose, 6-8% of croscarmellose sodium, 0.5-1.5% of magnesium stearate, and 0.2-0.5% of red iron oxide. The weight ratio of candesartan cilexetil to beta-cyclodextrin or its derivative is 1: (1-3). By controlling the crystallization temperature, a candesartan cilexetil C-type crystal with a diameter being less than 20 microns is obtained. The candesartan cilexetil C-type crystal has good fluidity, is used for preparing tablets, can help omit the premixing step, and is directly granulated without sieving so as to greatly facilitate the manufacture of oral solid preparations. 本发明属于医药制备技术领域，提供了一种坎地沙坦酯制剂，按照重量百分比包括以下成分：坎地沙坦酯3％-5％、β-环糊精或其衍生物1％-15％、乳糖20％-50％、预胶