Marker for colorectal cancer and application of marker

The invention relates to a marker for a colorectal cancer and an application of the marker, and in particular relates to abnormal expression of a GTF2H5 gene of the marker for the colorectal cancer, adetection method of the colorectal cancer and an application of the marker. The marker for the colorectal cancer includes a GTF2H5 gene abnormally expressed nucleic acid or/and proteins, and can realize test of GTF2H5 gene abnormality, nucleic acid or/and protein expression by using a gene sequencing technology, a chip semi-quantitative detection technology, a qPCR quantitative detection technology, a Western blotting semi-quantitative detection technology, an immunohistochemical staining technology, an in-situ hybridization technology and a liquid biopsy technology, and the test has better accuracy, stronger specificity and higher sensitivity. 本发明涉及一种结直肠癌标志物及其应用，具体涉及一种结直肠癌标志物GTF2H5基因的异常表达及其检测方法和应用，所述结直肠癌标志物包括GTF2H5基因异常表达的核酸或/和蛋白质，并通过运用基因测序技术、芯片半定量检测技术、qPCR定量检测技术、蛋白印迹半定量检测技术、免疫组织化学染色技术、原位杂交技术和液体活检技术能够实现GTF2H5基因异常