HA-Fc fusion protein and preparation method and vaccine thereof

The invention provides an HA-Fc fusion protein and a preparation method and vaccine thereof, and relates to the technical field of biological medicines. The HA-Fc fusion protein contains an avian influenza HA segment and an Fc region of an antibody, a C segment of the avian influenza HA segment is c...

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Bibliographische Detailangaben
Hauptverfasser:	CHENG LANLING, HE SUN, ZHANG YING, ZHANG GUOQING, YANG YING, LI JUNHUI, GAO DOU, PAN YIPING, ZHANG WEI, ZHOU BINGXIN, YU XINMAO, RAO TINGTING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides an HA-Fc fusion protein and a preparation method and vaccine thereof, and relates to the technical field of biological medicines. The HA-Fc fusion protein contains an avian influenza HA segment and an Fc region of an antibody, a C segment of the avian influenza HA segment is connected to the Fc region of the antibody, and the HA-Fc fusion protein is expressed by a CHO cell expression system. The HA-Fc fusion protein has high immunogenicity of an avian influenza antigen. 本发明提供了一种HA-Fc融合蛋白及其制备方法和疫苗，涉及生物医药技术领域。该HA-Fc融合蛋白含有禽流感HA片段和抗体的Fc区域，禽流感HA片段的C段连接抗体的Fc区域，并且HA-Fc融合蛋白由CHO细胞表达系统表达。该HA-Fc融合蛋白具有较高的禽流感抗原的免疫原性。