Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals

Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals

The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YAO XIEYI, DENG JUNJIE, WEI FANG, XU XUN, GU QING
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator YAO XIEYI
DENG JUNJIE
WEI FANG
XU XUN
GU QING
description The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the EWS protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the EWS can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that EWS or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, or treating diabetes, or preventing and treating d
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN110870917A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN110870917A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN110870917A3</originalsourceid><addsrcrecordid>eNqNjrEKwkAQRNNYiPoPa6dFIMFCLUOIWNkoWMqa28SF5O64u8R_8ivdQ7G2GmZ4M7vT5FVY23GNgY0G00D1ZN2CR1ebHmFVXc9rMA4Gmzpqhw6DmPAgR8KyBuvIoouVnpTM9KQDNJFxJJuSK8Y7BfKAWkV8FCLm0f6gMPTGcUuaPPv4xqfFtdxQPLIasPPzZNKI0OKrs2R5qC7lMSVrbuQt1tIPt_KU59lum-3zbbH5h3kDtc1ZKQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals</title><source>esp@cenet</source><creator>YAO XIEYI ; DENG JUNJIE ; WEI FANG ; XU XUN ; GU QING</creator><creatorcontrib>YAO XIEYI ; DENG JUNJIE ; WEI FANG ; XU XUN ; GU QING</creatorcontrib><description>The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the EWS protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the EWS can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that EWS or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, or treating diabetes, or preventing and treating d</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200310&amp;DB=EPODOC&amp;CC=CN&amp;NR=110870917A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200310&amp;DB=EPODOC&amp;CC=CN&amp;NR=110870917A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAO XIEYI</creatorcontrib><creatorcontrib>DENG JUNJIE</creatorcontrib><creatorcontrib>WEI FANG</creatorcontrib><creatorcontrib>XU XUN</creatorcontrib><creatorcontrib>GU QING</creatorcontrib><title>Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals</title><description>The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the EWS protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the EWS can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that EWS or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, or treating diabetes, or preventing and treating d</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjrEKwkAQRNNYiPoPa6dFIMFCLUOIWNkoWMqa28SF5O64u8R_8ivdQ7G2GmZ4M7vT5FVY23GNgY0G00D1ZN2CR1ebHmFVXc9rMA4Gmzpqhw6DmPAgR8KyBuvIoouVnpTM9KQDNJFxJJuSK8Y7BfKAWkV8FCLm0f6gMPTGcUuaPPv4xqfFtdxQPLIasPPzZNKI0OKrs2R5qC7lMSVrbuQt1tIPt_KU59lum-3zbbH5h3kDtc1ZKQ</recordid><startdate>20200310</startdate><enddate>20200310</enddate><creator>YAO XIEYI</creator><creator>DENG JUNJIE</creator><creator>WEI FANG</creator><creator>XU XUN</creator><creator>GU QING</creator><scope>EVB</scope></search><sort><creationdate>20200310</creationdate><title>Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals</title><author>YAO XIEYI ; DENG JUNJIE ; WEI FANG ; XU XUN ; GU QING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110870917A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YAO XIEYI</creatorcontrib><creatorcontrib>DENG JUNJIE</creatorcontrib><creatorcontrib>WEI FANG</creatorcontrib><creatorcontrib>XU XUN</creatorcontrib><creatorcontrib>GU QING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YAO XIEYI</au><au>DENG JUNJIE</au><au>WEI FANG</au><au>XU XUN</au><au>GU QING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals</title><date>2020-03-10</date><risdate>2020</risdate><abstract>The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the EWS protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the EWS can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that EWS or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, or treating diabetes, or preventing and treating d</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN110870917A
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A52%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=YAO%20XIEYI&rft.date=2020-03-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN110870917A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true