Application of Ewing sarcoma (EWS) or up-regulator thereof in preparing medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals

The invention relates to an application of Ewing sarcoma (EWS) or an up-regulator thereof in preparing a medicament for treating diabetes and preventing and treating tumorigenesis of diabetic individuals. The invention finds that the EWS obviously reduces the high ROS level and excessive activation of poly-(ADP-ribose)polymerase (PARP) in diabetic macrovascular and microvascular endothelia and retinal tissues; the EWS protein repairs damaged DNA by activating a homologous recombination repair (HR) pathway and a non-homology end joining (NHEJ) pathway, so that high-sugar toxicity of the vascular endothelia is relieved, and a retinal protection effect is shown; and the EWS can obviously enhance catabolism and AMPK activity of macrovascular endothelial cells and reduce JNK activity. It suggests that EWS or the up-regulator thereof can be used for preparing medicines for relieving dysfunction of diabetic vascular endothelia, or strengthening repair of DNA damage, or treating diabetes, or preventing and treating d