Application of PLCE1 inhibitor and recombinant p53 adenovirus

The invention provides an application of a phospholipase C epsilon-1 (PLCE1) inhibitor and a recombinant p53 adenovirus, and particularly relates to the application of a combination of the PLCE1 inhibitor and the recombinant p53 adenovirus in preparation of a medicament for treating esophageal squam...

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Bibliographische Detailangaben
Hauptverfasser:	LI JUN, LI FENG, TIAN YANXIA, PENG HAO, ZHENG YI, XIN HUAHUA, CUI XIAOBIN, CHEN FANGFANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides an application of a phospholipase C epsilon-1 (PLCE1) inhibitor and a recombinant p53 adenovirus, and particularly relates to the application of a combination of the PLCE1 inhibitor and the recombinant p53 adenovirus in preparation of a medicament for treating esophageal squamous cell carcinoma. The invention also provides the medicament for treating the esophageal squamouscell carcinoma, and the medicament is characterized by comprising the PLCE1 inhibitor and the recombinant p53 adenovirus. The invention belongs to the field of medicine, and provides the application of the combination of the PLCE1 inhibitor and the recombinant p53 adenovirus in the preparation of the medicament for treating the esophageal squamous cell carcinoma. The combination of the PLCE1 inhibitor and the recombinant p53 adenovirus can effectively inhibit the growth of esophageal squamous carcinoma cells and xenograft tumors; and based on the PLCE1 detection, through combined utilization of the recombinant p53 ade