CELL FACTORY HAVING IMPROVED IRON-SULFUR CLUSTER DELIVERY

The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes encoding polypeptides that enhance the biosynthesis of either bioti...

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Bibliographische Detailangaben
Hauptverfasser:	GENEE HANS JASPER, BALI ANNE PIHL, MYLING-PETERSEN NILS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes encoding polypeptides that enhance the biosynthesis of either biotin, lipoic acid or thiamine. The invention provides a method for producing either biotin, lipoic acidor thiamine using the genetically modified bacterium of the invention; as well as for the use of the genetically modified bacterial cell for either biotin, lipoic acid or thiamine production. 本发明提供了一种能够改善铁硫簇递送的经遗传修饰的细菌细胞，其特征在于编码突变的铁硫簇调节因子(IscR)的经修饰的基因以及编码增强生物素、硫辛酸或硫胺素的生物合成的多肽的一种或多种转基因。本发明提供了一种使用本发明的经遗传修饰的细菌生产生物素、硫辛酸或硫胺素的方法；以及所述经遗传修饰的细菌细胞在生产生物素、硫辛酸或硫胺素中的应用。