2-debenzoyl-2-acyl taxol deriatives and methods for making same

The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: wherein R1 is an alkyl or substituted alkyl; R2 is selected from the group consisting of H and C(O)Ra...

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Bibliographische Detailangaben
Hauptverfasser:	MILIND MORESHWAR GHARPURE, DAIVD G. K. KINGSTON, ASHOK GOPAL CHAUDHARY
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: wherein R1 is an alkyl or substituted alkyl; R2 is selected from the group consisting of H and C(O)Ra; R3 is selected from the group consisting of H, protecting groups, Rb, and C(O)Rb; R4 is selected from the group consisting of H and C(O)Rc, and wherein Ra, Rb, and Rc are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that Ra is other than phenyl and 3-hydroxyphenyl.