Subtractive multiple brush-off agent as well as preparation method and application thereof

The invention provides a subtractive multiple brush-off agent. The brush-off agent includes water-washable resin A and alcohol-washable resin B, wherein the ratio of the water-washable resin A to thealcohol-washable resin B is 1:(0.5-5). In the subtractive brush-off agent, the water-washable resin A and the alcohol-water-washable resin B are respectively applied to artificial leather for brush-off treatment at the ratio of 1:(0.5-5) or any other ratio; and after the leather is treated through a water washing process, each layer is treated by the water-washable resin A and the alcohol-washableresin B, after a part is dissolved and rubbed, a bottom color under each layer is exposed, so that color difference between one groove bottom of one corresponding top is formed, and the brush-off orwater washing effect is achieved. The brush-off agent adopts subtractive-type machine brush-off operation, and can realize the subtractive multiple brush-off artificial leather production on a large scale, and provide novel cha