Isoliquiritigenin nanosuspension and preparation method and application thereof

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an isoliquiritigenin nanosuspension and a preparation method and application thereof. The isoliquiritigenin nanosuspension is composed of isoliquiritigenin and a space stabilizer with a mass ratio of 1:(0.1-10), wherein the particle size is 200-700 nm, and the electric potential is -30 mV to 20 mV. The space stabilizer is one or more of hydroxypropyl cellulose, povidone K30, hydroxypropyl methyl cellulose, polyethylene glycol 6000, vitamin E polyethylene glycol succinate and croscarmellose sodium. The isoliquiritigenin nanosuspension is high in drug loading capacity and good in stability, and the cumulative dissolution rate and dissolution rate are also remarkably increased. In-vitro cell experiments show that: compared with an isoliquiritigenin raw material medicine, the capacity of inducing lung cancer A549 cell apoptosis is remarkably improved, the capacities of being taken in by tumor cells and inhibiting cancer