Polypeptide, application thereof and DPP-IV (dipeptidyl peptidase 4) inhibitors or hypoglycemic drugs

The present invention relates to a polypeptide compound Leu-His-Val-Asp-Pro-Glu-Asn for the inhibition of dipeptidyl peptidase IV (DPP-IV) activity and for lowering blood glucose, which has an amino acid sequence of Leu-His-Val-Asp-Pro-Glu-Asn. The polypeptide Leu-His-Val-Asp-Pro-Glu-Asn has DPP-IV...

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Bibliographische Detailangaben
Hauptverfasser:	YE MINGLIANG, JIN YAN, YAN JIAZE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a polypeptide compound Leu-His-Val-Asp-Pro-Glu-Asn for the inhibition of dipeptidyl peptidase IV (DPP-IV) activity and for lowering blood glucose, which has an amino acid sequence of Leu-His-Val-Asp-Pro-Glu-Asn. The polypeptide Leu-His-Val-Asp-Pro-Glu-Asn has DPP-IV inhibition activity and hypoglycemic activity and has a good application prospect as health productsand drug lead compounds for reducing blood glucose and treating type II diabetes. 本发明涉及抑制二肽基肽酶(DPP-Ⅳ，dipeptidyl peptidaseⅣ)活性及降血糖的一种多肽化合物Leu-His-Val-Asp-Pro-Glu-Asn，它的氨基酸序列为Leu-His-Val-Asp-Pro-Glu-Asn。多肽Leu-His-Val-Asp-Pro-Glu-Asn具有DPP-Ⅳ抑制活性及降血糖活性，作为降血糖以及治疗II型糖尿病的保健品和药物先导化合物具有良好的应用前景。