Ipratropium bromide monohydrate

The invention provides an ipratropium bromide monohydrate and a preparation method thereof. The method specifically comprises: adding ipratropium bromide into a benign solvent, heating, stirring, dissolving, adding a certain amount of purified water in a dropwise manner, adding a poor solvent in a dropwise manner after the solution is clarified, and carrying out programmed cooling crystallizationto obtain the high-purity ipratropium bromide monohydrate. According to the invention, the preparation method is simple to operate, high in product yield and high in product purity, and the prepared ipratropium bromide monohydrate has good solubility and good chemical stability and is suitable for industrial production. 本发明提供了一种异丙托溴铵一水合物及其制备方法。具体步骤为：将异丙托溴铵加入到良性溶剂中后，加热搅拌溶解并滴加一定量的纯化水，溶液澄清后，滴加不良溶剂，通过程序降温析晶得到高纯度的异丙托溴铵一水合物。本发明所述的制备方法操作简单、产品收率高、纯度高，并且本发明提供的异丙托溴铵一水合物具有较好的溶解性与化学稳定性，适合于工业化生产。