Tetrandrine nano suspension and preparation method and application thereof

The invention relates to the field of pharmaceutical preparations, in particular to a tetrandrine nano suspension, which is prepared by nanocrystallizing tetrandrine and a stabilizer through a dispersion medium; the particle size of the tetrandrine nano suspension is 50-600 nm, the absolute value of Zeta potential is 10-40 mV, and a mass ratio of tetrandrine to the stabilizer is 1:(0.1-1), the invention specifically discloses a preparation method of the tetrandrine nano suspension and application of the tetrandrine nano suspension in the preparation of anti-tumor drugs. The tetrandrine nano suspension has the particle size of 50-600 nm, good stability and can evidently increase the solubility and dissolution rate of tetrandrine; compared with the bulk pharmaceutical chemical tetrandrine, the tetrandrine nano suspension has evident in-vitro inhibition rate for tumor cells, has evidently improved apoptosis rate and cell uptake rate, has evidently increased dissolution rate and anti-tumoractivity of tetrandrine,