Sulfa-drug half-antigen, artificial antigen and application thereof in immunodetection
The invention discloses a sulfa-drug half-antigen, an artificial antigen and an application thereof in immunodetection and belongs to the field of immunodetection. A structure of the half-antigen hastwo aminobenzene sulfonamide structures, so that the prepared artificial antigen has a more outstandi...
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| creator | HUANG JIAYI WU XIUFENG WANG YINGYING LIU YUANGAO LI BIN SU ZHENXIAN |
| description | The invention discloses a sulfa-drug half-antigen, an artificial antigen and an application thereof in immunodetection and belongs to the field of immunodetection. A structure of the half-antigen hastwo aminobenzene sulfonamide structures, so that the prepared artificial antigen has a more outstanding spatial structure, the presenting of a common characteristic group aminobenzene sulfonamide of sulfa-drugs is better facilitated, and the immunogenicity of the antigen is improved; the artificial antigen is combined with an ELISA detection technology, and an IC50 value of sulfadimidine is 0.5 microgram per liter; and a sulfa-drug colloidal gold immunochromatography test paper strip prepared by using the artificial antigen can implement rapid and accurate detection.
本发明公开了一种磺胺类药物半抗原、人工抗原及其在免疫检测中的应用，属于免疫检测领域。半抗原结构中具有两个胺基苯磺酰胺的结构，使得制备而成的人工抗原的空间结构更突出，更有利于呈现磺胺类药物的共有特征基团胺基苯磺酰胺，提高了抗原的免疫原性，将人工抗原结合ELISA检测技术，磺胺二甲嘧啶的IC50值为0.5μg/L；使用本发明制备的磺胺类药物胶体金免疫层析试纸条，可以实行快速、准确的检测。 |
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本发明公开了一种磺胺类药物半抗原、人工抗原及其在免疫检测中的应用，属于免疫检测领域。半抗原结构中具有两个胺基苯磺酰胺的结构，使得制备而成的人工抗原的空间结构更突出，更有利于呈现磺胺类药物的共有特征基团胺基苯磺酰胺，提高了抗原的免疫原性，将人工抗原结合ELISA检测技术，磺胺二甲嘧啶的IC50值为0.5μg/L；使用本发明制备的磺胺类药物胶体金免疫层析试纸条，可以实行快速、准确的检测。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; TESTING</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200221&DB=EPODOC&CC=CN&NR=110818599A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200221&DB=EPODOC&CC=CN&NR=110818599A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUANG JIAYI</creatorcontrib><creatorcontrib>WU XIUFENG</creatorcontrib><creatorcontrib>WANG YINGYING</creatorcontrib><creatorcontrib>LIU YUANGAO</creatorcontrib><creatorcontrib>LI BIN</creatorcontrib><creatorcontrib>SU ZHENXIAN</creatorcontrib><title>Sulfa-drug half-antigen, artificial antigen and application thereof in immunodetection</title><description>The invention discloses a sulfa-drug half-antigen, an artificial antigen and an application thereof in immunodetection and belongs to the field of immunodetection. A structure of the half-antigen hastwo aminobenzene sulfonamide structures, so that the prepared artificial antigen has a more outstanding spatial structure, the presenting of a common characteristic group aminobenzene sulfonamide of sulfa-drugs is better facilitated, and the immunogenicity of the antigen is improved; the artificial antigen is combined with an ELISA detection technology, and an IC50 value of sulfadimidine is 0.5 microgram per liter; and a sulfa-drug colloidal gold immunochromatography test paper strip prepared by using the artificial antigen can implement rapid and accurate detection.
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本发明公开了一种磺胺类药物半抗原、人工抗原及其在免疫检测中的应用，属于免疫检测领域。半抗原结构中具有两个胺基苯磺酰胺的结构，使得制备而成的人工抗原的空间结构更突出，更有利于呈现磺胺类药物的共有特征基团胺基苯磺酰胺，提高了抗原的免疫原性，将人工抗原结合ELISA检测技术，磺胺二甲嘧啶的IC50值为0.5μg/L；使用本发明制备的磺胺类药物胶体金免疫层析试纸条，可以实行快速、准确的检测。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Sulfa-drug half-antigen, artificial antigen and application thereof in immunodetection |
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