Secondary amine derivative synthesized through rare earth catalysis, and preparation method thereof
The invention discloses a secondary amine derivative synthesized through rare earth catalysis, and a preparation method thereof. According to the preparation method, the secondary amine derivative isprepared by carrying out a reaction on reactants of secondary amide and pinacol borane; a rare earth...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a secondary amine derivative synthesized through rare earth catalysis, and a preparation method thereof. According to the preparation method, the secondary amine derivative isprepared by carrying out a reaction on reactants of secondary amide and pinacol borane; a rare earth catalyst bis(trimethylsilyl) amino yttrium is added; the reaction temperature is 100-140 DEG C, andthe reaction time is 20-25 h; the whole reaction is carried out under a normal pressure, and the reaction conditions are mild, easy to achieve and safe; the method is simple and convenient to operateand high in reaction selectivity, can directly synthesize the target product without intermediate product separation, can obtain the target product only through a reaction under a normal pressure, issimple in reaction process, has the yield of 90% at most, substantially simplifies the process engineering, reduces the energy consumption, and has high yield; the reaction raw materials are stable and easy to store; a series o |
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