Application of blue light activated blebbistatin analogue to killing of drug-resistant bacteria and method
The invention relates to an application of a blue light activated blebbistatin analogue to killing of drug-resistant bacteria and a method. The blebbistatin analogue comprises (R)-blebbistatin; the drug-resistant bacteria comprise staphylococcus aureus, escherichia coli, enterococcus, pseudomonas ae...
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| creator | YUAN JING LIU LEI ZHOU ZIYUAN GAO LEI LIU YINGXIA LI MINGDE ZHANG MINGXIA XIE YONGLI HUANG NAIQI |
| description | The invention relates to an application of a blue light activated blebbistatin analogue to killing of drug-resistant bacteria and a method. The blebbistatin analogue comprises (R)-blebbistatin; the drug-resistant bacteria comprise staphylococcus aureus, escherichia coli, enterococcus, pseudomonas aeruginosa and acinetobacter baumannii; and blue light wavelength is 420 nm. (R)-blebbistatin withoutmammalian targets or bioactivity is utilized for killing the drug-resistant bacteria such as the staphylococcus aureus, the escherichia coli, the enterococcus, the pseudomonas aeruginosa and the acinetobacter baumannii after being activated by blue light with wavelength of 420 nm and has a remarkable bactericidal effect. According to the invention, it is safe to adopt (R)-blebbistatin molecules ina living body for 60 min treatment; and besides, the bactericidal efficiency is improved with increase of illumination time, and the risk of induced resistance is eliminated. The application and themethod are not limited by b |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING |
| title | Application of blue light activated blebbistatin analogue to killing of drug-resistant bacteria and method |
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