Application of blue light activated blebbistatin analogue to killing of drug-resistant bacteria and method

The invention relates to an application of a blue light activated blebbistatin analogue to killing of drug-resistant bacteria and a method. The blebbistatin analogue comprises (R)-blebbistatin; the drug-resistant bacteria comprise staphylococcus aureus, escherichia coli, enterococcus, pseudomonas aeruginosa and acinetobacter baumannii; and blue light wavelength is 420 nm. (R)-blebbistatin withoutmammalian targets or bioactivity is utilized for killing the drug-resistant bacteria such as the staphylococcus aureus, the escherichia coli, the enterococcus, the pseudomonas aeruginosa and the acinetobacter baumannii after being activated by blue light with wavelength of 420 nm and has a remarkable bactericidal effect. According to the invention, it is safe to adopt (R)-blebbistatin molecules ina living body for 60 min treatment; and besides, the bactericidal efficiency is improved with increase of illumination time, and the risk of induced resistance is eliminated. The application and themethod are not limited by b