Magnetic solid-phase extraction agent for enriching Guanfu base A and preparation method and enrichment method of magnetic solid-phase extraction agent

The invention relates to the field of analysis pretreatment of effective components in traditional Chinese medicinal materials, in particular to a magnetic solid-phase extraction agent for enriching Guanfu base A and preparation and enrichment methods of the magnetic solid-phase extraction agent. The preparation method of the magnetic solid-phase extraction agent comprises the following steps: taking CoFe2O4/GS nano-particles modified by the Guanfu base A as a template molecule, NVP and AA as functional monomers, MBA as a cross-linking agent, H2O2-Vc as an initiator and KH570 as a coupling agent to serve as a magnetic carrier, and preparing the magnetic solid-phase extraction agent by adopting a surface molecular imprinting technology. According to the invention, the molecular imprinting technology is combined with a sulfonic acid functionalization method for magnetic solid-phase extraction of the Guanfu base A; the magnetic solid-phase extraction efficiency is improved through dual effects, the consumption o