pH sensitive sweet wormwood herb artesunate polymer prodrug, preparation method thereof, and medical composition for treating colon cancer

The invention provides a pH sensitive sweet wormwood herb artesunate polymer prodrug, and a preparation method and application thereof, as well as a medicine for assisting in treatment of colon cancer, and relates to the technical field of medicines. For the pH sensitive sweet wormwood herb artesunate polymer prodrug, sweet wormwood herb artesunate is coupled with a pH sensitive polymer through anester bond. The ester bonds are used for constructing a coupler of the sweet wormwood herb artesunate and the pH sensitive polymer, and the obtained pH sensitive sweet wormwood herb artesunate polymer prodrug has favorable water-solubility and stability. The systemic circulation time can be prolonged, and the pH sensitive sweet wormwood herb artesunate polymer prodrug has the characteristic of quick medicine release under the acid condition. Compared with the sweet wormwood herb artesunate, the pH sensitive sweet wormwood herb artesunate polymer prodrug provided by the invention has higher cytotoxicity and more notab