Callicarpa arborea essence compound and its derivative, preparation method and application thereof, and pharmaceutical composition

The invention discloses a Callicarpa arborea essence compound and its derivative, and a preparation method and an application thereof, and relates to the technical field of medicines. The Callicarpa arborea essence compound is extracted from Callicarpa arborea or Callicarpa integerrima, and is wide in source and simple to prepare. The compound and its derivative have an obvious inhibiting effect on an NLRP3 signal path, can be widely applied to preparation of medicines for treating inflammatory diseases, and have a good treatment effect on various inflammatory body-mediated diseases. A pharmaceutical composition comprises the Callicarpa arborea essence compound and its derivative, and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition can be used for treating various inflammatory body-mediated diseases. 一种木紫珠素类化合物及其衍生物，涉及药物技术领域，以及它们的制备方法和应用，该木紫珠素类化合物由木紫珠或全缘叶紫珠中提取得到，来源广泛，制备简单。其对于NLRP3信号通路具有明显的抑制作用，可以广泛应用在治疗炎症性疾病的药物的制备中，对于由炎症小体介导的各类疾病均有较好的治疗效果。一种药物组合物，其包括上述木紫珠素类化合物及其衍生物，以及药学上可接收的辅料。