7-hydroxy-2-quinolone-dithiocarbamate cholinesterase inhibitor
The invention relates to the field of pharmaceutical chemistry, in particular to a 7-hydroxy-2-quinolone-dithiocarbamate compound shown as a formula I (Please see the specifications for the formula I). A pharmacodynamic experiment proves that the compound can serve as a cholinesterase inhibitor and...
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| creator | FU JIE GU MIN BAO FENGQI |
| description | The invention relates to the field of pharmaceutical chemistry, in particular to a 7-hydroxy-2-quinolone-dithiocarbamate compound shown as a formula I (Please see the specifications for the formula I). A pharmacodynamic experiment proves that the compound can serve as a cholinesterase inhibitor and can be clinically used for treating Alzheimer's disease (AD). In the formula I, R1 represents -H or-CH3, R2 represents -H or -CH3, R3 represents cyclic secondary amine substituent groups shown in the specification, and n is equal to 2-6.
本发明涉及药物化学领域，具体涉及了一种7-羟基-2-喹诺酮-二硫代氨基甲酸酯类化合物（式I），药效学实验证明，本发明的这类化合物可作为胆碱酯酶抑制剂，临床可用于治疗阿尔茨海默病。R表示-H或-CH；R表示-H或-CH；R表示以下取基团；等环状仲胺取代基；n=2-6。 |
| format | Patent |
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本发明涉及药物化学领域，具体涉及了一种7-羟基-2-喹诺酮-二硫代氨基甲酸酯类化合物（式I），药效学实验证明，本发明的这类化合物可作为胆碱酯酶抑制剂，临床可用于治疗阿尔茨海默病。R表示-H或-CH；R表示-H或-CH；R表示以下取基团；等环状仲胺取代基；n=2-6。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200211&DB=EPODOC&CC=CN&NR=110776459A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200211&DB=EPODOC&CC=CN&NR=110776459A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FU JIE</creatorcontrib><creatorcontrib>GU MIN</creatorcontrib><creatorcontrib>BAO FENGQI</creatorcontrib><title>7-hydroxy-2-quinolone-dithiocarbamate cholinesterase inhibitor</title><description>The invention relates to the field of pharmaceutical chemistry, in particular to a 7-hydroxy-2-quinolone-dithiocarbamate compound shown as a formula I (Please see the specifications for the formula I). A pharmacodynamic experiment proves that the compound can serve as a cholinesterase inhibitor and can be clinically used for treating Alzheimer's disease (AD). In the formula I, R1 represents -H or-CH3, R2 represents -H or -CH3, R3 represents cyclic secondary amine substituent groups shown in the specification, and n is equal to 2-6.
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本发明涉及药物化学领域，具体涉及了一种7-羟基-2-喹诺酮-二硫代氨基甲酸酯类化合物（式I），药效学实验证明，本发明的这类化合物可作为胆碱酯酶抑制剂，临床可用于治疗阿尔茨海默病。R表示-H或-CH；R表示-H或-CH；R表示以下取基团；等环状仲胺取代基；n=2-6。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 7-hydroxy-2-quinolone-dithiocarbamate cholinesterase inhibitor |
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