7-hydroxy-2-quinolone-dithiocarbamate cholinesterase inhibitor

The invention relates to the field of pharmaceutical chemistry, in particular to a 7-hydroxy-2-quinolone-dithiocarbamate compound shown as a formula I (Please see the specifications for the formula I). A pharmacodynamic experiment proves that the compound can serve as a cholinesterase inhibitor and...

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Bibliographische Detailangaben
Hauptverfasser: FU JIE, GU MIN, BAO FENGQI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to the field of pharmaceutical chemistry, in particular to a 7-hydroxy-2-quinolone-dithiocarbamate compound shown as a formula I (Please see the specifications for the formula I). A pharmacodynamic experiment proves that the compound can serve as a cholinesterase inhibitor and can be clinically used for treating Alzheimer's disease (AD). In the formula I, R1 represents -H or-CH3, R2 represents -H or -CH3, R3 represents cyclic secondary amine substituent groups shown in the specification, and n is equal to 2-6. 本发明涉及药物化学领域,具体涉及了一种7-羟基-2-喹诺酮-二硫代氨基甲酸酯类化合物(式I),药效学实验证明,本发明的这类化合物可作为胆碱酯酶抑制剂,临床可用于治疗阿尔茨海默病。R表示-H或-CH;R表示-H或-CH;R表示以下取基团;等环状仲胺取代基;n=2-6。