HETEROCYCLIC COMPOUNDS AS EPHA4 INHIBITORS

New methods and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. The method includes administering to a subject in need thereof an effective amount of asmall molecule compound inhibitor for EphA4 signaling. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4signaling. 本发明提供用于治疗由过度活化的EphA4信号传导引起或加剧的疾病的新方法和试剂盒。所述方法包括向对其有需要的个体投与有效量的用于EphA4信号传导的小分子化合物抑制剂。本发明还提供用于鉴别附加化合物的方法，所述化合物作为治疗剂能够用于治疗涉及EphA4信号过度活化的病状。