Application of DLX1, HOXC6 and PCA3 in preparing prostate cancer marker and kit of DLX1, HOXC6 and PCA3

The invention discloses application of DLX1, HOXC6 and PCA3 in preparing a prostate cancer marker and a kit of DLX1, HOXC6 and PCA3. The kit uses a multiple qRT-PCR technology to simultaneously detectDLX1/HOXC6/PCA3 mRNA in a urine sample, meanwhile, the PSA mRNA is used as a reference to establish...

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Hauptverfasser: KONG FANPING, ZHU YOUJIE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of DLX1, HOXC6 and PCA3 in preparing a prostate cancer marker and a kit of DLX1, HOXC6 and PCA3. The kit uses a multiple qRT-PCR technology to simultaneously detectDLX1/HOXC6/PCA3 mRNA in a urine sample, meanwhile, the PSA mRNA is used as a reference to establish a Logistic regression model as an early diagnostic marker for prostate cancer. The kit is tested ina combined mode through a plurality of markers to achieve a high coincidence rate for the clinical and pathological results of prostate cancer. 本发明公开了一种DLX1,HOXC6和PCA3在制备前列腺癌标志物中的应用及其试剂盒。该试剂盒使用多重qRT-PCR技术,在一份尿液样本中同时检测DLX1/HOXC6/PCA3 mRNA,同时以PSA mRNA作参照,建立Logistic回归模型,作为前列腺癌早期诊断标志物。该试剂盒通过多个标志物联合检测,达到了对前列腺癌临床病理结果极高的符合率。