SMALL MOLECULE INHIBITORS OF BCL-2-ASSOCIATED DEATH PROMOTER (BAD) PHOSPHORYLATION

SMALL MOLECULE INHIBITORS OF BCL-2-ASSOCIATED DEATH PROMOTER (BAD) PHOSPHORYLATION

The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylationand have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cance...

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Bibliographische Detailangaben
Hauptverfasser: VENKATACHALAIAH SRINIVASA, LOBIE PETER EDWARD, PANDEY VIJAY KUMAR, CHAKRABHAVI DHANANJAYA MOHAN, RANGAPPA SHOBITH, KANCHUGARAKOPPAL SUBBEGOWDA RANGAPPA, SALUNDI BASSAPPA
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylationand have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer. 本发明涉及通式(I)化合物：其中R、n、R、R和R如本文中所限定。所述化合物是Bcl-2相关死亡促进因子(BAD)磷酸化的抑制剂并且具有抗凋亡活性，并且可用于治疗癌症，特别是乳腺癌、子宫内膜癌、卵巢癌、肝癌、结肠癌、前列腺癌或胰腺癌。