Nucleic acid probe of targeted telomere

The invention discloses a nucleic acid probe of a targeted telomere. A nucleic acid probe sequence is 5'-CCCTA-E-CCCTAA-Gly-3'; and the E in the nucleic acid probe sequence is a fluorophore cumarin acid OC7 labeled peptide nucleic acid framework. The fluorophore cumarin acid OC7 is embedded into the peptide nucleic acid sequence of the targeted telomere through synthesizing the peptide nucleic acid framework Fmoc-aeg(Alloc)-OH protected by Fmoc and Alloc protecting groups; and a nucleic acid probe molecular tool is provided for the telomere detection. 本发明公开了一种靶向端粒的核酸探针，其核酸探针序列为5'-CCCTA-E-CCCTAA-Gly-3'，核酸探针序列中E是荧光基团香豆素酸OC7标记的肽核酸骨架。本发明通过合成Fmoc和Alloc保护基团保护的肽核酸骨架Fmoc-aeg(Alloc)-OH将荧光基团香豆素酸OC7嵌入到靶向端粒的肽核酸序列中，为端粒的检测提供了一种核酸探针分子工具。