Articaine hydrochloride crystal form II preparation method

The invention belongs to the technical field of chemical synthesis, and particularly relates to an articaine hydrochloride crystal form II preparation method, which comprises: adding articaine hydrochloride into isopropanol, carrying out heating reflux to completely dissolve articaine hydrochloride, cooling to 30-45 DEG C within 2-4 h, maintaining the temperature at 30-45 DEG C, stirring to carryout first-stage crystallization for 10-20 h, cooling to -10-0 DEG C within 2-6 h, carrying out second-stage crystallization, filtering, and drying to obtain the articaine hydrochloride crystal form II. According to the invention, recrystallization is carried out by using a single solvent isopropanol, such that the high-purity articaine hydrochloride crystal form II is obtained. 本发明属于化学合成技术领域，具体涉及一种盐酸阿替卡因晶型Ⅱ的制备方法。该方法包括如下步骤：盐酸阿替卡因加入异丙醇中，加热回流使盐酸阿替因全部溶解，降温，2-4小时降温至30-45℃，并维持30-45℃，搅拌进行第一段析晶10-20小时，然后2-6小时降温至-10-0℃进行第二段析晶，过滤，干燥，即得。本发明采用单一溶剂异丙醇进行重结晶，获得了高纯度的盐酸阿替卡因晶型Ⅱ。