MULTIVALENT VACCINE COMPOSITION

The present invention relates to stable, immunogenic combination vaccme(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium letani, Bordetel!a pertussis and Hepatit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SABALE RAJENDRA NARAYAN, JIANG BAOMING, KADAM RAVINDRA BAPURAO, GLASS ROGER, DHERE RAJEEV MHALASAKANT, PISAL SAMBHAJI SHANKAR, KAMBLE ABHIJEET SANJEEV, ZADE JAGDISH KAMALAJI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to stable, immunogenic combination vaccme(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium letani, Bordetel!a pertussis and Hepatitis B virus. The invention particularly provides a multivalent combination vaccine comprising of i) significantly dose reduced Salk IPV or Sabin IPV (IPV) antigens prepared by utilizing improved methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum recovery of D-antigen and ii) Injectable heat inactivated Rotavirus antigen(s) obtained from Rotavirus (CDC-9) strains that provides a broad cross-protective immunity among human rotavirus strains, iii) Hib PRP -carrier protein conjugate having improved stability and immunogenicity wherein said Hib PRP -earner protein conjugate is initially prepared by using novel conjugation process and subsequently blended at lowtemperature in presence