Method for Preparing Tubulysin Key Fragment Tuv

The invention belongs to the technical field of chemical synthesis and relates to a method for preparing a key fragment Tuv of a natural product Tubulysin with anticancer activity. The method of the invention is simple in operation, simple in route and high in yield, in particular, the technical route of the method of the invention is high in selectivity, and can amplify and prepare Tuv fragmentsof Tubulysin V. The key fragment Tuv of the natural product Tubulysin with anticancer activity prepared by the method of the invention is helpful for drug formation evaluation and preclinical evaluation of the compound. 本发明属于化学合成技术领域，涉及一种制备具有抗癌活性天然产物Tubulysin的关键片段Tuv的方法。本发明方法操作简单，路线简洁，收率较高，尤其本发明方法的技术路线高选择性、可放大制备Tubulysin V的Tuv片段。本发明方法制得的具有抗癌活性天然产物Tubulysin的关键片段Tuv有助于该类化合物的成药性评价及临床前评价。