Anti-PD-L1/anti-LAG3 bispecific antibody and uses thereof

The invention provides an anti-PD-L1/anti-LAG3 bispecific antibody, which can effectively block the interaction between PD-L1 and PD-1 and the interaction between LAG3 and a ligand (MHC II molecules,FGL1, etc.). The bispecific antibody is highly affinity to PD-L1 proteins (human PD-L1 protein, for e...

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Bibliographische Detailangaben
Hauptverfasser:	LEE YANG-SEUNG, CHEONG ZAE-KWANG, LEE SANG-HEUN, CHEONG YI-JUNG, KIM YANGOO, FANG LEI, PARK YUNG-DON, PARK EUN-IN, YU WON-WOOK, JIANG WENQING, KIM CHO-SIK
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides an anti-PD-L1/anti-LAG3 bispecific antibody, which can effectively block the interaction between PD-L1 and PD-1 and the interaction between LAG3 and a ligand (MHC II molecules,FGL1, etc.). The bispecific antibody is highly affinity to PD-L1 proteins (human PD-L1 protein, for example) and LAG3 proteins (human LAG3 protein, for example). The invention also provides an antibody and segment that has specificity on PD-L1 or LAG3 proteins; or an antibody and segment that has specificity on one or more other antigens. 本披露提供了抗PD-L1/抗LAG3双特异性抗体，其能够有效阻断在PD-L1与其受体PD-1之间以及在LAG3与其配体(例如MHC II类分子和FGL1)之间的相互作用。该双特异性抗体可以对PD-L1蛋白(例如人PD-L1蛋白)和LAG3蛋白(例如人LAG3蛋白)二者均具有高结合亲和力。还提供了对单独的该PD-L1或LAG3蛋白具有特异性的抗体和片段，或具有额外的对一种或多种其他抗原的特异性的抗体和片段。