Natamycin polymer micelle eye drop and preparation method thereof

The invention relates to a natamycin polymer micelle eye drop and a preparation method thereof, belongs to the technical field of ophthalmic disease treatment and aims to solve the problem that a conventional natamycin eye drop is too high in use frequency. The invention provides the natamycin polymer micelle eye drop which comprises a natamycin polymer micelle and a phosphate buffer in a certainmass volume ratio, wherein the natamycin polymer micelle comprises 10-30% in mass percentage of natamycin and the balance of a polyethylene glycol-polymethylacrylic acid glyceride block copolymer. Thepolyethylene glycol-polymethylacrylic acid glyceride block copolymer is put into ethanol to form a cross-linking micelle through self assembling, and the natamycin is coated by the micelle to preparethe natamycin polymer micelle eye drop, so that the release time of the natamycin can be prolonged, the medicine use times can be reduced, the problem that the patient compliance is poor because of frequent medicine use can be