Method for synthesizing cyclo-heptapeptide Rhizonin A

The invention discloses a method for synthesizing a cyclo-heptapeptide Rhizonin A. The method comprises the steps: subjecting a known L-N-Boc-valine-D-C-OMe-valine, which serves as a starting raw material, to acid hydrolysis, then, subjecting the acid hydrolysis product to condensation with commercial D-N-Boc-isoleucine so as to obtain a tripeptide, carrying out acid hydrolysis, then, subjecting the acid hydrolysis product to condensation with L-N-Me-3-(3-furyl)alanine, and carrying out acid hydrolysis, so as to obtain a tetrapeptide; and then, subjecting L-N-Me-alanine to acid hydrolysis, then, subjecting the acid hydrolysis product to condensation with L-N-Boc-leucine so as to obtain a dipeptide, subjecting the dipeptide to acid hydrolysis, then, subjecting the acid hydrolysis product tocondensation with D-N-Me-3-(3-furyl)alanine, carrying out basic hydrolysis so as to obtain a tripeptide, subjecting the tripeptide and the before-mentioned tetrapeptide to condensation so as to obtain a heptapeptide, and sub