Preparation method of 1,5-tetrahydronaphthyridine derivative

The invention discloses a preparation method of a 1,5-tetrahydronaphthyridine derivative. According to the invention, the 1,5-tetrahydronaphthyridine derivative with diversified structures is synthesized by catalyzing the activation/functionalization a pyridine hydrocarbon bond with rare earth. Specifically, the 1,5-tetrahydronaphthyridine derivative is prepared in a rare earth catalytic system and in a nitrogen protection atmosphere with various 3-alkenylbutylaminopyridine as a raw material. The method disclosed by the invention has the advantages of wide sources or easy preparation of raw materials, simple and convenient operation, controllable selectivity, high yield, mild conditions and good universality. 本发明公开了一种1,5-四氢萘啶衍生物的制备方法，本发明通过稀土催化吡啶碳氢键活化/官能团化从而实现结构多样化的1,5-四氢萘啶衍生物的合成。具体是在稀土催化体系下，氮气保护氛围下，以各种3-烯丁氨基吡啶为原料，制备1,5-四氢萘啶衍生物。本发明方法原料来源广泛或易于制备，操作简便、选择性可控，收率高，条件温和，普适性广。