MicroRNA328 for regulating expression of TERT gene and application of microRNA328

The present invention discloses a microRNA328 for regulating expression of TERT gene and an application of the microRNA328, and provides uses of the microRNA328 or a substance inhibiting expression ofthe microRNA328. The miR328 is found to have a significant inhibitory effect on an expression level of TERT mRNA in Hela cells and an oligonucleotide inhibitor of the miR-328 has a significant up-regulation effect on the expression level of the TERT gene mRNA in the Hela cells. The inhibitor of the miR-328 significantly increases angiogenic capacity of EPC. The EPC transfected by the inhibitor ofthe miR-328 significantly inhibits differentiation of NSCs into glial cells. Studies show that using miRNAs as targets or tools to enhance telomerase activity provide theoretical basis for treatmentof neurological diseases of vascular dementia (VD), etc. and have potential clinical application value. 本发明公开了调节TERT基因表达的microRNA328及其应用。本发明提供了microRNA328或抑制其表达的物质的用途。本发明发现miR328对Hela细胞TERT mRNA表达水平有显著的抑制作用，miR-328的寡核苷酸抑制剂对Hela