Compounds useful as inhibitors of ATR kinase and different solid forms thereof

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this inventio...

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Bibliographische Detailangaben
Hauptverfasser: PIERARD FRANCOISE, DAVIS CHRIS, CHARRIER JEAN-DAMIEN, STORCK PIERRE-HENRI, STUDLEY JOHN, ETXEBARRIA I JARDI GORKA, PINDER JOANNE, KNEGTEL RONALD, FRAYSSE DAMIEN, PANESAR MANINDER, AHMAD NADIA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of thecompounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula (I-l) or (I-A); wherein the variables are as defined herein. 本发明涉及用作ATR蛋白激酶抑制剂的化合物。本发明涉及包含本发明化合物的药学上可接受的组合物;使用本发明化合物治疗各种疾病、障碍和病症的方法;制备本发明化合物的方法;本发明化合物的制备中间体;和本发明化合物的固体形式。本发明化合物具有式I-1或I-A;其中变量是如本文定义的。