Percutaneous sustained-release patch for resisting schizophrenia

The invention discloses a percutaneous sustained-release patch for resisting schizophrenia, and belongs to the field of pharmaceutical preparations. The percutaneous sustained-release patch is composed of a backing layer, a pressure-sensitive adhesive storage layer and an anti-sticking layer. The pr...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG QI, JIANG CHANGZHAO, GAO WENYAN, YE JINCUI, CAO XIAOCHUN, ZHENG GAOLI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a percutaneous sustained-release patch for resisting schizophrenia, and belongs to the field of pharmaceutical preparations. The percutaneous sustained-release patch is composed of a backing layer, a pressure-sensitive adhesive storage layer and an anti-sticking layer. The pressure-sensitive adhesive storage layer comprises 1 to 12 percent of aripiprazole, 10 to 35 percentof a penetration enhancer, 60 to 80 percent of a viscous polymer and 0.5 to 2 percent of a drug stabilizer. According to the percutaneous sustained-release patch, medicines can permeate the skin to reach higher blood concentration within 24 hours, the blood medicine concentration can be kept stable within 5-6 days, and the patch is expected to be clinically used for achieving the effects of long acting, convenience in use and good medication compliance of a patient. The pressure-sensitive adhesive storage layer of the percutaneous sustained-release patch comprises the medicines, the penetration enhancer, the viscous p