RGDV-modified heptacyclic aldehyde, synthesis, antithrombotic activity and application thereof

The invention discloses Arg-Gly-Asp-Val modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine[1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Val]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diket...

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Bibliographische Detailangaben
Hauptverfasser:	SHI LINYI, FENG QIQI, ZHAO MING, PENG SHIQI, GUI LIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses Arg-Gly-Asp-Val modified heptacyclic aldehyde shown as the following formula in the specification, namely (2'S, 5'S)-tetrahydropyrazine[1', 2': 1, 6]bis{(1R)-[1-ethyl-Arg-Gly-Asp-Val]-2, 3, 4, 9-tetrahydro-1H-pyridine[3, 4-b]diindyl}-1', 4'-diketone, a preparation method thereof and anti-venous thrombosis activity thereof. Therefore, the invention discloses application of the Arg-Gly-Asp-Val modified heptacyclic aldehyde in preparation of anti-venous thrombosis drugs. 本发明公开了下式的Arg-Gly-Asp-Val修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R)-[1-乙基-Arg-Gly-Asp-Val]-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗静脉血栓活性，因而本发明公开了它在制备抗静脉血栓药物中的应用。